Concentration of 300 microM 3,4-dihydroxybenzaldehyde caused 50% growth inhibition of human cancer cell U937. However, we will accept natural product applications through a number of investigator-initiated grant mechanisms. As a result, 18 compounds have been isolated. Bioactivity assays showed that 2-(4-hydroxybenzyl) quinazolin-4(3H)-one (2) and methyl 4-hydroxyphenylacetate (5) had potent inhibitory activity against tobacco mosaic virus (TMV), and the new compound 1 had moderate inhibitory activity against TMV and human gastric cancer cell SGC-7901. Res. Moreover, present results demonstrated that the baicalin, bioactive compound of WSBE, was able to penetrate into the skin following topical application, which was confirmed by the HPLC analysis using rat model. The microbial transformation of 18beta-glycyrrhetinic acid (1) by Cunninghamella elegans afforded a metabolite, 3beta,7beta-dihydroxy-11-oxo-olean-12-en-30-oic acid (2), while fermentation of 1 with Fusarium lini afforded a metabolite, 3,11-dioxo-olean-12-en-30-oic acid (3). Special Issue "Medicinal Plants and Natural Product Research" Special Issue Editors Special Issue Information Keywords; Published Papers; A special issue of Plants (ISSN 2223-7747). In the present study we describe the anti-allergic effect of topically applied Scutellaria bacalensis aqueous extract (WSBE) in suppressing 2,4-dinitrochlorobenzene (DNCB)-induced ACD in BALB/c mice. Compounds 3-5 exhibited significant antimicrobial activities against Staphylococcus aureus and Bacillus subtilis. This is limited to a very small number of high-priority products and conditions. Apoptotic effect of prodigiosin was higher than doxorubicin in HT-29 cells. Their structures were elucidated by using spectroscopic methods, mainly by an extensive NMR analysis. In search of anti-inflammatory lead compounds from traditional Chinese medicines, a bioassay-guided phytochemical study on Melastoma dodecandrum was carried out. Grandiflorenic acid was efficiently metabolised by the fungus. Isolation and bioactivity evaluation of microbial metabolites of resveratrol, Biotransformation of ent-kaur-16-en-19-oic acid by Psilocybe cubensis, Biotransformation of ent-kaur-16-en-19-oic acid by Absidia blakesleeana and Rhizopus oligosporus, Antigenotoxic effect of allicin against estradiol-17-induced genotoxic damage in cultured mammalian cells, 5,6-De-epoxy-5-en-7-one-17-hydroxy withaferin A, a new cytotoxic steroid from Withania somnifera L. Dunal leaves, Microbial transformation of 18-glycyrrhetinic acid by Cunninghamella elegans and Fusarium lini, and lipoxygenase inhibitory activity of transformed products, Spasmolytic activity of trachylobanes ent-7α-acetoxytrachyloban-18- oic acid and ent-7α-hydroxytrachyloban-18-oic acid isolated from Xylopia langsdorfiana A. St-Hil. The methanol extract of the whole plant of Hedyotis chrysotricha demonstrated cytotoxicity against SK-HEP-1 human hepatocarcinoma cells in a primary screening for novel antitumour agents. The first total and efficient synthesis of a naturally occurring acetylenic alcohol 15-methyltricosa-2,4-diyne-1,6-diol (strongylodiol-G) derived from marine sponge involving nine steps has been described. Now, it has been isolated from the leaves, as well. The structure of the new compound was established by analysis of spectroscopic data. Furthermore, MDI attenuated DNA-binding activity of NF-κB by inhibiting the phosphorylation of IκB. The structure of 1 was elucidated based on spectral analysis and chemical transformations. Biotranformation of ent-kaur-16-en-19-oic acid (1) using Psilocybe cubensis resulted in hydroxylated products. Evaluation of biological activity of metabolites through a series of mammalian cell based assays indicated that resveratrol tends to lose its anti-inflammatory, cytotoxic and anti-oxidant activities with the substitution of its hydroxyl groups. Putative mutants of Trichoderma reesei FCBP-364 were selected on the basis of their bigger hydrolysing zone formation and compared to the parental strains quantitatively. Search Funded PhD Projects, Programs & Scholarships in natural products. The structures were established by spectroscopic techniques and X-ray crystallography. Although carefully collected, accuracy cannot be guaranteed. Compounds 1, 3-6 and 8 inhibited lipopolysaccharide-stimulated nitric oxide (NO) production and inducible NO synthase expression in RAW 264.7 macrophages with IC50 values of 9.24 ± 1.20, 21.37 ± 2.02, 23.07 ± 1.58, 9.86 ± 0.98, 19.05 ± 1.66 and 11.3 ± 1.54 μM, respectively. The former, in addition, gave 5-methoxyresveratrol-3-O-β-glucoside (2) with the latter yielding 5-methoxyresveratrol-3-O-sulphate (3). Their structures were elucidated by means of physicochemical properties and spectroscopic methods (1D, 2D-NMR and MS). First time drugs, drug precursors, and/or complementary health adjuvants ent-7α-acetoxytrachyloban-18-oic acid 1. Two cancerous cellular lines structures of these compounds were evaluated for the treatment of inflammatory diseases research. Dichroism spectroscopy the basis of extensive spectroscopic analysis 's external surface and of. 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